Lesions in the Hippocampus and Substantia Nigra of Wistar Rats’ Brains Induced by Organophosphate Insecticide

As little is known about the neurotoxicity of histological structure brain, this study focuses on side four- to six-month-old adult Wistar rat brains, which were examined after 0.1 mg\g organophosphate had been administered orally. In study, lesions mainly localized at hippocampus and substantia nigra (compacta pars) region. Distinct areas necrotic apoptotic tissues detected in CA1, CA2, dentate gyrus compacta pars nigra. Programmed cell death was observed as early 72 hours treatment necrosis some brain regions. Moreover, Lewy bodies noticed The most important symptoms parkinsonism pars). These decreased neurons, increased neuronal melanin glial cells. degeneration neurons reported polymorphic pyramidal layers. data showed an increase density axon membrane several changes axis structure, such disappearance myelin sheath along axis.